# GALNT14

Source: https://onco.cc/targets/galnt14/  
OnCo record `galnt14` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GALNT14 (Polypeptide N-acetylgalactosaminyltransferase 14) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.

## Summary

Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: polypeptide N-acetylgalactosaminyltransferase 14; Polypeptide N-acetylgalactosaminyltransferase 14; GalNac-T10; FLJ12691; GalNac-T14
- Tags: cancer-genes-wave
- Symbol: GALNT14
- Class: enzyme
- Biology: Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Location: Golgi apparatus membrane (UniProt). Locus 2p23.1 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:22946: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22946
- UniProt Q96FL9: https://www.uniprot.org/uniprotkb/Q96FL9/entry
- NCBI Gene 79623: https://www.ncbi.nlm.nih.gov/gene/79623
- Ensembl ENSG00000158089: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158089

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/galnt14.json