# GAS6

Source: https://onco.cc/targets/gas6/  
OnCo record `gas6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.

## Summary

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Docetaxel.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: growth arrest specific 6; Growth arrest-specific protein 6; FLJ34709; DKFZp666G247; AXLLG
- Tags: cancer-genes-wave
- Symbol: GAS6
- Class: other
- Biology: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. Location: Secreted (UniProt). Locus 13q34 (HGNC).
- Where found: Prostate cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oral Squamous Cell Carcinoma.

## Sources

- HGNC HGNC:4168: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4168
- UniProt Q14393: https://www.uniprot.org/uniprotkb/Q14393/entry
- NCBI Gene 2621: https://www.ncbi.nlm.nih.gov/gene/2621
- Ensembl ENSG00000183087: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183087

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/gas6.json