# GATA3

Source: https://onco.cc/targets/gata3/  
OnCo record `gata3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GATA3 (Trans-acting T-cell-specific transcription factor GATA-3) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Leukaemia and 2 more.

## Summary

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cobimetinib. Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes affected pathway 0.56, literature 0.99, genetic association 0.37, somatic mutation 0.87, animal model 0.65). IntOGen calls it a driver in 7 cohorts (3 activating, 3 loss-of-function), covering Acute Lymphoblastic Leukaemia, Invasive Breast Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: GATA binding protein 3; Trans-acting T-cell-specific transcription factor GATA-3
- Tags: cancer-genes-wave
- Symbol: GATA3
- Class: transcription
- Biology: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signalling to drive differentiation of inflammation-resolving alternatively activated macrophages. Location: Nucleus (UniProt). Locus 10p14 (HGNC).
- Where found: Breast cancer: Open Targets association 0.74 with breast cancer (MONDO_0007254); IntOGen driver in 6 cohorts (BRCA); Non-Hodgkin lymphoma: Open Targets association 0.66 with non-Hodgkin lymphoma (MONDO_0018908); Leukaemia: Open Targets association 0.66 with leukaemia (MONDO_0005059); Hodgkin lymphoma: Open Targets association 0.51 with Hodgkins lymphoma (MONDO_0004952); Acute lymphoblastic leukaemia: Open Targets association 0.62 with acute lymphoblastic leukaemia (MONDO_0004967); IntOGen driver in 1 cohort (ALL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Histiocytosis-Lymphadenopathy Plus Syndrome.

## Sources

- HGNC HGNC:4172: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4172
- UniProt P23771: https://www.uniprot.org/uniprotkb/P23771/entry
- NCBI Gene 2625: https://www.ncbi.nlm.nih.gov/gene/2625
- Ensembl ENSG00000107485: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107485

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/gata3.json