# GDF7

Source: https://onco.cc/targets/gdf7/  
OnCo record `gdf7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GDF7 (Growth/differentiation factor 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

May play an active role in the motor area of the primate neocortex.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.67, animal model 0.71, genetic association 0.80).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: growth differentiation factor 7; Growth/differentiation factor 7; BMP12
- Tags: cancer-genes-wave
- Symbol: GDF7
- Class: other
- Biology: May play an active role in the motor area of the primate neocortex. Location: Secreted (UniProt). Locus 2p24.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4222: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4222
- UniProt Q7Z4P5: https://www.uniprot.org/uniprotkb/Q7Z4P5/entry
- NCBI Gene 151449: https://www.ncbi.nlm.nih.gov/gene/151449
- Ensembl ENSG00000143869: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143869

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/gdf7.json