# Generate:Biomedicines

Source: https://onco.cc/companies/generate-biomedicines/  
OnCo record `generate-biomedicines` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Generative-AI protein design company (Flagship) that went public in 2026 and is testing an antibody that neutralises leaked ADC payload to reduce side effects.

## Summary

Generate:Biomedicines went public in early 2026 (~$400M IPO). Oncology programmes: GB-4362, an MMAE neutraliser with FDA Fast Track for enfortumab vedotin toxicity in urothelial cancer (trial-in-progress at ESMO 2026), and GB-5267, a MUC16 CAR-T with Roswell Park. First AI-designed antibody advanced to phase 3 in a non-oncology indication.

## Fields

- Kind: Company
- Last checked: 2026-09-04
- Tags: frontier
- HQ: Somerville, MA
- Type: ai-software
- Website: https://generatebiomedicines.com
- Ticker: GBIO

## Sources

- Q2 2026 business update: https://www.biospace.com/press-releases/generate-biomedicines-inc-reports-second-quarter-2026-financial-results-and-provides-business-update

## Connected records

- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- fronts: [AI & Computation](https://onco.cc/fronts/ai-computation/), [Antibody-Drug Conjugates](https://onco.cc/fronts/adcs/), [Immunotherapy](https://onco.cc/fronts/immunotherapy/)
- technologies: [ADC payload neutralisers](https://onco.cc/technologies/adc-payload-neutralizer/), [AI-driven drug & target discovery](https://onco.cc/technologies/ai-drug-design/), [CAR-T cell therapy](https://onco.cc/technologies/car-t/), [De novo designed protein binders](https://onco.cc/technologies/de-novo-protein-design/)
- drugs: [Enfortumab vedotin](https://onco.cc/drugs/enfortumab-vedotin/)
- institutions: [Roswell Park Comprehensive Cancer Center](https://onco.cc/institutions/roswell-park/)
- companies: [Flagship Pioneering](https://onco.cc/companies/flagship-pioneering/)
- bottlenecks: [The valley of death between lab and product](https://onco.cc/bottlenecks/b-translational-valley/)
- ideas: [AI-designed proteins that grip the floppy parts of cancer drivers](https://onco.cc/ideas/idea-bio1-ai-binders-disordered-regions/), [Macrocyclic peptides to cover protein surfaces that pills cannot](https://onco.cc/ideas/idea-bio1-macrocycle-ppi-campaign/)
- roadmaps: [Drug discovery roadmap: screening in mice → maps of dependency → designing in silico](https://onco.cc/roadmaps/drug-discovery-roadmap/)

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JSON: https://onco.cc/api/v1/entities/generate-biomedicines.json