# GeoVax

Source: https://onco.cc/companies/geovax/  
OnCo record `geovax` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GeoVax is a Georgia company that makes vaccines against infections and one cancer treatment, Gedeptin. Gedeptin is injected into a tumour so that the tumour cells switch on a drug given afterwards, and it has been tested in advanced head and neck cancer.

## Summary

GeoVax Labs, Inc., of Smyrna, Georgia, describes itself in its November 2026 registration statement as a clinical-stage biotechnology company developing vaccines and immunotherapies against infectious diseases and solid tumours. Its near-term priority is a Modified Vaccinia Ankara vaccine for mpox and smallpox. Its lead oncology programme is Gedeptin, a gene-directed enzyme prodrug therapy licensed from PNP Therapeutics in September 2021: a replication-deficient adenovirus carries a non-human gene into tumour cells, and the enzyme it makes converts the prodrug fludarabine phosphate into an active anti-tumour compound inside the tumour. The company reports a completed multi-site phase 1b/2a trial (PNP-002, NCT03754933) of repeat cycles in advanced head and neck squamous cell carcinoma, an FDA orphan drug designation for intratumoral treatment of accessible oral and pharyngeal cancers, and plans a phase 2 trial with a checkpoint inhibitor before curative surgery in the second half of 2027.

## Fields

- Kind: Company
- Last checked: 2026-11-04
- Also known as: GeoVax Labs, Inc.
- HQ: Smyrna, GA
- Type: biotech
- Website: https://www.geovax.com/
- Ticker: GOVX

## Notes

- Read on 4 November 2026 in the S-1 filed with the SEC that day. The filing does not give the date of the Gedeptin orphan designation, so no dated designation is recorded. The trial NCT03754933 has no OnCo record.

## Sources

- SEC: GeoVax Labs Form S-1, November 2026: https://www.sec.gov/Archives/edgar/data/832489/000143774926034729/govx20261102_s1.htm
- Official website: https://www.geovax.com/

## Connected records

- fronts: [Immunotherapy](https://onco.cc/fronts/immunotherapy/)
- drugs: [Gedeptin](https://onco.cc/drugs/gedeptin/)

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JSON: https://onco.cc/api/v1/entities/geovax.json