# Gintemetostat

Source: https://onco.cc/drugs/gintemetostat/  
OnCo record `gintemetostat` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Gintemetostat is an experimental small molecule from K36 Therapeutics, in phase 1 trials for relapsed or refractory multiple myeloma).

## Summary

Gintemetostat (KTX-1001) is a small molecule (oral) from K36 Therapeutics. An oral, selective inhibitor of NSD2 (also called MMSET or WHSC1), which is overexpressed in multiple myeloma with the t(4;14) translocation; it is designed to reduce H3K36me2 levels and reverse oncogenic transcriptional programmes. Its furthest stage is phase 1, for relapsed or refractory multiple myeloma (t(4;14)). ClinicalTrials.gov registers it in one study linked below. NCT05651932 (K36-MMSET-001) recruiting per v2 API, with combination cohorts. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Also known as: KTX-1001
- Tags: pipeline; ctgov-ingest
- Code: KTX-1001
- Modality: Small molecule (oral)
- Mechanism: An oral, selective inhibitor of NSD2 (also called MMSET or WHSC1), which is overexpressed in multiple myeloma with the t(4;14) translocation; it is designed to reduce H3K36me2 levels and reverse oncogenic transcriptional programmes.

## Sources

- K36 Therapeutics: k36tx.com: https://www.k36tx.com/
- K36 Therapeutics: k36tx.com: https://www.k36tx.com/
- K36 Therapeutics: k36tx.com: https://www.k36tx.com/about-ktx-1001
- K36 Therapeutics: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT05651932
- ClinicalTrials.gov: trials of KTX-1001: https://clinicaltrials.gov/search?intr=KTX-1001

## Connected records

- cancers: [Relapsed or refractory multiple myeloma](https://onco.cc/cancers/myeloma-relapsed-refractory/)
- targets: [NSD2](https://onco.cc/targets/nsd2/)
- companies: [K36 Therapeutics](https://onco.cc/companies/k36-therapeutics/)
- trials: [A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma](https://onco.cc/trials/nct05651932/)

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