# GlobeImmune

Source: https://onco.cc/companies/globeimmune/  
OnCo record `globeimmune` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GlobeImmune is a Colorado biotech that used whole heat-killed yeast to deliver tumour antigens to the immune system; GI-6301 carried the transcription factor brachyury for chordoma and other cancers.

## Summary

GlobeImmune developed Tarmogens, heat-killed recombinant Saccharomyces cerevisiae yeast engineered to express disease antigens, which are taken up by dendritic cells and drive antigen-specific T-cell responses. GI-6301 expresses brachyury, a transcription factor that drives epithelial-to-mesenchymal transition and is the defining marker of chordoma; it was studied with radiotherapy in a randomised phase 2 chordoma trial run with the National Cancer Institute. GI-4000, targeting mutant RAS, was tested in pancreatic cancer and lung cancer.

## Fields

- Kind: Company
- Last checked: 2026-09-17
- Also known as: GlobeImmune, Inc.
- Tags: drug-maker
- HQ: Louisville, Colorado
- Type: biotech

## Connected records

- drugs: [GI-6301](https://onco.cc/drugs/gi-6301/)

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JSON: https://onco.cc/api/v1/entities/globeimmune.json