# GMPS

Source: https://onco.cc/targets/gmps/  
OnCo record `gmps` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GMPS (GMP synthase [glutamine-hydrolysing]) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma.

## Summary

Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: guanosine monophosphate synthase; GMP synthase [glutamine-hydrolyzing]; GATD7
- Tags: cancer-genes-wave
- Symbol: GMPS
- Class: oncogene
- Biology: Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. Location: Cytoplasm, cytosol (UniProt). Locus 3q25.31 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4378: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4378
- UniProt P49915: https://www.uniprot.org/uniprotkb/P49915/entry
- NCBI Gene 8833: https://www.ncbi.nlm.nih.gov/gene/8833
- Ensembl ENSG00000163655: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163655

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/gmps.json