# GNB1

Source: https://onco.cc/targets/gnb1/  
OnCo record `gnb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GNB1 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.

## Summary

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: G protein subunit beta 1; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- Tags: cancer-genes-wave
- Symbol: GNB1
- Class: other
- Biology: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Locus 1p36.33 (HGNC).
- Where found: Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.55 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4396: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4396
- UniProt P62873: https://www.uniprot.org/uniprotkb/P62873/entry
- NCBI Gene 2782: https://www.ncbi.nlm.nih.gov/gene/2782
- Ensembl ENSG00000078369: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078369

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/gnb1.json