# GPAA1

Source: https://onco.cc/targets/gpaa1/  
OnCo record `gpaa1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GPAA1 (GPI-anchor transamidase component GPAA1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.

## Summary

Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: glycosylphosphatidylinositol anchor attachment 1; GPI-anchor transamidase component GPAA1; GAA1; hGAA1
- Tags: cancer-genes-wave
- Symbol: GPAA1
- Class: oncogene
- Biology: Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor. Location: Endoplasmic reticulum membrane (UniProt). Locus 8q24.3 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4446: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4446
- UniProt O43292: https://www.uniprot.org/uniprotkb/O43292/entry
- NCBI Gene 8733: https://www.ncbi.nlm.nih.gov/gene/8733
- Ensembl ENSG00000197858: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197858

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/)

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JSON: https://onco.cc/api/v1/entities/gpaa1.json