# GPC5

Source: https://onco.cc/targets/gpc5/  
OnCo record `gpc5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.

## Summary

Cell surface proteoglycan that bears heparan sulfate.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.54, somatic mutation 0.43). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Cholangiocarcinoma, Ovarian Epithelial Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: glypican 5; Glypican-5
- Tags: cancer-genes-wave
- Symbol: GPC5
- Class: tumor-suppressor
- Biology: Cell surface proteoglycan that bears heparan sulfate. Location: Cell membrane; Secreted, extracellular space (UniProt). Locus 13q31.3 (HGNC).
- Where found: Ovarian cancer: IntOGen driver in 1 cohort (OVT); Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4453: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4453
- UniProt P78333: https://www.uniprot.org/uniprotkb/P78333/entry
- NCBI Gene 2262: https://www.ncbi.nlm.nih.gov/gene/2262
- Ensembl ENSG00000179399: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179399

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/gpc5.json