# GRB7

Source: https://onco.cc/targets/grb7/  
OnCo record `grb7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GRB7 is an adaptor protein gene that sits next to HER2 on chromosome 17 and is copied along with it in HER2-positive cancers.

## Summary

17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes GRB7 as an adapter that interacts with numerous receptor kinases and promotes activation of STAT3, AKT and MAPK; it is one of the genes in the Oncotype DX HER2 group.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: growth factor receptor bound protein 7
- Tags: cansim-terms
- Symbol: GRB7
- Class: other
- Biology: Adapter protein that binds the cytoplasmic domain of receptor kinases and modulates downstream signalling, promoting activation of STAT3, AKT1 and MAPK1/3 and of HRAS (UniProt Q14451).
- Where found: Locus 17q12 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:4567: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4567
- UniProt Q14451: https://www.uniprot.org/uniprotkb/Q14451/entry

## Connected records

- targets: [HER2](https://onco.cc/targets/her2/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)
- pathways: [PI3K / AKT / mTOR](https://onco.cc/pathways/pi3k-akt-mtor/), [RAS / RAF / MEK / ERK (MAPK)](https://onco.cc/pathways/ras-mapk/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/)

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JSON: https://onco.cc/api/v1/entities/grb7.json