# Great Ormond Street Hospital for Children

Source: https://onco.cc/institutions/great-ormond-street/  
OnCo record `great-ormond-street` (Institution). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

London's children's hospital, where gene-edited 'universal' CAR-T cells were first given to a child with leukaemia.

## Summary

Founded in 1852, Great Ormond Street Hospital is the UK's largest children's hospital and, with the UCL Great Ormond Street Institute of Child Health, one of Europe's leading paediatric research centres. In 2015 Waseem Qasim's team treated an infant with refractory leukaemia using TALEN-edited allogeneic CAR-T cells, the first such use in humans, and in 2022 the team delivered the first base-edited CAR-T (CD7-directed) for T-cell leukaemia. The hospital runs one of the UK's largest paediatric oncology and haematology services, including bone marrow transplantation, neuro-oncology and neuroblastoma programmes, and hosts the Zayed Centre for Research into Rare Disease in Children. It is a principal treatment centre for London and a national referral site for rare childhood cancers.

## Fields

- Kind: Institution
- Last checked: 2026-09-09
- Also known as: GOSH; UCL Great Ormond Street Institute of Child Health
- City: London, GB
- Type: hospital
- Website: https://www.gosh.nhs.uk

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Great_Ormond_Street_Hospital_for_Children_NHS_Foundation_Trust
- Homepage: https://www.gosh.nhs.uk
- UCL GOS Institute of Child Health: https://www.ucl.ac.uk/child-health/

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/)
- fronts: [Cell Therapy](https://onco.cc/fronts/cell-therapy/)
- technologies: [Allogeneic (off-the-shelf) cell therapy](https://onco.cc/technologies/allogeneic-cell-therapy/), [CAR-T cell therapy](https://onco.cc/technologies/car-t/), [Germline (hereditary) testing](https://onco.cc/technologies/germline-testing/)
- targets: [CD19](https://onco.cc/targets/cd19/)
- institutions: [North Central London Cancer Alliance](https://onco.cc/institutions/north-central-london-cancer-alliance/), [University College London Hospitals / UCL Cancer Institute](https://onco.cc/institutions/uclh/)
- people: [Darren R. Hargrave](https://onco.cc/people/darren-hargrave/), [Karl Munslow-Ong](https://onco.cc/people/karl-munslow-ong/), [Sophia Varadkar](https://onco.cc/people/sophia-varadkar/), [Waseem Qasim](https://onco.cc/people/waseem-qasim/)
- bottlenecks: [Manufacturing cost and time for living and radioactive medicines](https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/), [Rare and paediatric cancers without markets](https://onco.cc/bottlenecks/b-rare-cancers/)
- companies: [Innovative Therapies for Children with Cancer (ITCC)](https://onco.cc/companies/itcc/)

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JSON: https://onco.cc/api/v1/entities/great-ormond-street.json