# GRHPR

Source: https://onco.cc/targets/grhpr/  
OnCo record `grhpr` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GRHPR (Glyoxylate reductase/hydroxypyruvate reductase) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidises D-glycerate to hydroxypyruvate.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: glyoxylate and hydroxypyruvate reductase; Glyoxylate reductase/hydroxypyruvate reductase; PH2
- Tags: cancer-genes-wave
- Symbol: GRHPR
- Class: enzyme
- Biology: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidises D-glycerate to hydroxypyruvate. Locus 9p13.2 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4570: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4570
- UniProt Q9UBQ7: https://www.uniprot.org/uniprotkb/Q9UBQ7/entry
- NCBI Gene 9380: https://www.ncbi.nlm.nih.gov/gene/9380
- Ensembl ENSG00000137106: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137106

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

---
JSON: https://onco.cc/api/v1/entities/grhpr.json