# GSTP1

Source: https://onco.cc/targets/gstp1/  
OnCo record `gstp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.

## Summary

Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers.

CIViC holds 2 clinical evidence items and 0 assertions across 3 variants, naming Paclitaxel, Carboplatin, Cisplatin and FOLFOX Regimen.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: glutathione S-transferase pi 1; Glutathione S-transferase P; FAEES3; GST3
- Tags: cancer-genes-wave
- Symbol: GSTP1
- Class: enzyme
- Biology: Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Location: Cytoplasm; Mitochondrion; Nucleus (UniProt). Locus 11q13.2 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease; Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4638: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4638
- UniProt P09211: https://www.uniprot.org/uniprotkb/P09211/entry
- NCBI Gene 2950: https://www.ncbi.nlm.nih.gov/gene/2950
- Ensembl ENSG00000084207: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000084207

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/gstp1.json