# GTF2I

Source: https://onco.cc/targets/gtf2i/  
OnCo record `gtf2i` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GTF2I (General transcription factor II-I) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thymoma.

## Summary

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Thymoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: general transcription factor IIi; General transcription factor II-I; TFII-I; BAP-135; BTKAP1; IB291; WBSCR6
- Tags: cancer-genes-wave
- Symbol: GTF2I
- Class: oncogene
- Biology: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Location: Cytoplasm; Nucleus (UniProt). Locus 7q11.23 (HGNC).
- Where found: Thymoma: IntOGen driver in 1 cohort (THYM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4659: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4659
- UniProt P78347: https://www.uniprot.org/uniprotkb/P78347/entry
- NCBI Gene 2969: https://www.ncbi.nlm.nih.gov/gene/2969
- Ensembl ENSG00000263001: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000263001

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Thymoma (WHO types A, AB, B1, B2 and B3)](https://onco.cc/cancers/thymoma/)

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JSON: https://onco.cc/api/v1/entities/gtf2i.json