# H1-2

Source: https://onco.cc/targets/h1-2/  
OnCo record `h1-2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

H1-2 (Histone H1.2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibres. Compared to other histone H1 variants, H1-2 plays an essential role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: H1.2 linker histone, cluster member; Histone H1.2; H1.2; H1s-1; H1c; H1F2; HIST1H1C
- Tags: cancer-genes-wave
- Symbol: H1-2
- Class: other
- Biology: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibres. Compared to other histone H1 variants, H1-2 plays an essential role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants. Histone H1-2 also acts as a histone reader: specifically recognises and binds histone H3 trimethylated at 'lys-27' (H3K27me3). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication. Together with histone H1-3, histone H1-2 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-2 has a high affinity for exons and regulates splicing by affecting RNA polymerase II (RNAPII) elongation. Location: Nucleus; Nucleus, nucleolus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4716: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4716
- UniProt P16403: https://www.uniprot.org/uniprotkb/P16403/entry
- NCBI Gene 3006: https://www.ncbi.nlm.nih.gov/gene/3006
- Ensembl ENSG00000187837: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187837

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/h1-2.json