# H2BC5

Source: https://onco.cc/targets/h2bc5/  
OnCo record `h2bc5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

H2BC5 (Histone H2B type 1-D) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: H2B clustered histone 5; Histone H2B type 1-D; H2B/b; H2BFB; HIST1H2BD
- Tags: cancer-genes-wave
- Symbol: H2BC5
- Class: other
- Biology: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4747: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4747
- UniProt P58876: https://www.uniprot.org/uniprotkb/P58876/entry
- NCBI Gene 3017: https://www.ncbi.nlm.nih.gov/gene/3017
- Ensembl ENSG00000158373: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158373

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

---
JSON: https://onco.cc/api/v1/entities/h2bc5.json