# H3C2

Source: https://onco.cc/targets/h3c2/  
OnCo record `h3c2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

H3C2 (Histone H3.1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Bladder & urothelial cancer, Oesophageal cancer and 5 more.

## Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

CIViC holds 7 clinical evidence items and 1 assertion across 1 variant. Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes literature 0.04, affected pathway 0.76, somatic mutation 0.78). IntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Oesophageal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: H3 clustered histone 2; Histone H3.1; H3/l; H3FL; HIST1H3B
- Tags: cancer-genes-wave
- Symbol: H3C2
- Class: oncogene
- Biology: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
- Where found: Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA); Bladder & urothelial cancer: IntOGen driver in 2 cohorts (BLCA); Oesophageal cancer: IntOGen driver in 1 cohort (ESCA); Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908); Diffuse midline glioma, H3 K27-altered: CIViC evidence names this disease; Glioma & glioblastoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 7 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Anaplastic Astrocytoma; Brain Glioblastoma Multiforme; Diffuse Astrocytoma.

## Sources

- HGNC HGNC:4776: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4776
- UniProt P68431: https://www.uniprot.org/uniprotkb/P68431/entry
- NCBI Gene 8358: https://www.ncbi.nlm.nih.gov/gene/8358
- Ensembl ENSG00000286522: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000286522

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Diffuse midline glioma, H3 K27-altered (including DIPG)](https://onco.cc/cancers/dipg-dmg/), [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/)

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JSON: https://onco.cc/api/v1/entities/h3c2.json