# H3C4

Source: https://onco.cc/targets/h3c4/  
OnCo record `h3c4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

H3C4 (Histone H3.1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: H3 clustered histone 4; Histone H3.1; H3/b; H3FB; HIST1H3D
- Tags: cancer-genes-wave
- Symbol: H3C4
- Class: other
- Biology: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Posterior Fossa Group A Ependymoma.

## Sources

- HGNC HGNC:4767: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4767
- UniProt P68431: https://www.uniprot.org/uniprotkb/P68431/entry
- NCBI Gene 8351: https://www.ncbi.nlm.nih.gov/gene/8351
- Ensembl ENSG00000197409: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197409

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/h3c4.json