# H4C9

Source: https://onco.cc/targets/h4c9/  
OnCo record `h4c9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

H4C9 (Histone H4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.

## Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes affected pathway 0.76, animal model 0.46, somatic mutation 0.49). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: H4 clustered histone 9; Histone H4; H4/m; H4FM; HIST1H4I
- Tags: cancer-genes-wave
- Symbol: H4C9
- Class: oncogene
- Biology: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).
- Where found: Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4793: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4793
- UniProt P62805: https://www.uniprot.org/uniprotkb/P62805/entry
- NCBI Gene 8294: https://www.ncbi.nlm.nih.gov/gene/8294
- Ensembl ENSG00000276180: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000276180

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/)

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JSON: https://onco.cc/api/v1/entities/h4c9.json