# HABP2

Source: https://onco.cc/targets/habp2/  
OnCo record `habp2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HABP2 (Factor VII-activating protease) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.

## Summary

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.67, genetic association 0.67, genetic literature 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: hyaluronan binding protein 2; Factor VII-activating protease; HGFAL
- Tags: cancer-genes-wave
- Symbol: HABP2
- Class: enzyme
- Biology: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumour suppressor negatively regulating cell proliferation and cell migration. Location: Secreted (UniProt). Locus 10q25.3 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.51 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4798: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4798
- UniProt Q14520: https://www.uniprot.org/uniprotkb/Q14520/entry
- NCBI Gene 3026: https://www.ncbi.nlm.nih.gov/gene/3026
- Ensembl ENSG00000148702: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148702

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/habp2.json