# HB-200

Source: https://onco.cc/drugs/hb-200/  
OnCo record `hb-200` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HB-200 is a vaccine built from two harmless engineered viruses that teach the immune system to attack the HPV16 proteins inside cervical and throat cancers. It has been tested with pembrolizumab in HPV16-positive head and neck cancer.

## Summary

HB-200 is Hookipa Pharma's therapeutic vaccine for HPV16-positive cancers, made of two arenavirus vectors, HB-201 (based on lymphocytic choriomeningitis virus) and HB-202 (based on Pichinde virus), that express the same HPV16 E6/E7 fusion antigen. Alternating the two vectors avoids immunity against the vector itself and produced some of the largest antigen-specific T-cell expansions reported for a cancer vaccine.

It was given intravenously with pembrolizumab in phase 1/2 trials in recurrent or metastatic HPV16-positive head and neck squamous cell carcinoma, with response rates in the first-line setting above those expected from pembrolizumab alone. It is named on the recurrent or metastatic head and neck cancer page among the newer immunotherapy approaches for HPV-positive disease.

## Fields

- Kind: Treatment
- Status: phase-2
- Last checked: 2026-09-17
- Also known as: HB-201; HB-202; Eseba-vec
- Tags: subtype-drugs-wave
- Code: HB-200
- Modality: Arenavirus-vector therapeutic vaccine (HPV16 E6/E7)
- Mechanism: Two replicating arenavirus vectors (lymphocytic choriomeningitis and Pichinde virus) each carrying a non-oncogenic HPV16 E6/E7 fusion protein, given alternately to raise very high frequencies of E6- and E7-specific killer T cells against HPV16-driven tumours.

## Connected records

- drugs: [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- cancers: [Recurrent or metastatic head and neck squamous cell carcinoma](https://onco.cc/cancers/recurrent-metastatic-hnscc/)
- technologies: [HPV & HBV vaccination](https://onco.cc/technologies/hpv-vaccine/)
- companies: [Hookipa Pharma](https://onco.cc/companies/hookipa-pharma/)

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JSON: https://onco.cc/api/v1/entities/hb-200.json