# HBB

Source: https://onco.cc/targets/hbb/  
OnCo record `hbb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signalling, these properties implicate it as a regulator of pain and inflammation.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: hemoglobin subunit beta; Hemoglobin subunit beta; CD113t-C; beta-globin
- Tags: cancer-genes-wave
- Symbol: HBB
- Class: other
- Biology: Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signalling, these properties implicate it as a regulator of pain and inflammation. Locus 11p15.4 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: SMARCB1-deficient Renal Medullary Carcinoma.

## Sources

- HGNC HGNC:4827: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4827
- UniProt P68871: https://www.uniprot.org/uniprotkb/P68871/entry
- NCBI Gene 3043: https://www.ncbi.nlm.nih.gov/gene/3043
- Ensembl ENSG00000244734: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000244734

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

---
JSON: https://onco.cc/api/v1/entities/hbb.json