# HBEGF

Source: https://onco.cc/targets/hbegf/  
OnCo record `hbegf` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HBEGF (Proheparin-binding EGF-like growth factor) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.95, genetic association 0.00, clinical 0.08).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heparin binding EGF like growth factor; Proheparin-binding EGF-like growth factor; HB-EGF; HEGFL
- Tags: cancer-genes-wave
- Symbol: HBEGF
- Class: other
- Biology: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 5q31.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.08. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3059: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3059
- UniProt Q99075: https://www.uniprot.org/uniprotkb/Q99075/entry
- NCBI Gene 1839: https://www.ncbi.nlm.nih.gov/gene/1839
- Ensembl ENSG00000113070: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113070

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/hbegf.json