# Hepatitis B and C as cancer causes

Source: https://onco.cc/terms/hbv-hcv/  
OnCo record `hbv-hcv` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Two viruses cause most liver cancer worldwide. One is preventable by vaccine, the other curable with pills, which makes liver cancer one of the most preventable cancers.

## Summary

HBV (integration and chronic inflammation) and HCV (chronic inflammation, cirrhosis) account for the majority of HCC globally. Universal HBV vaccination in Taiwan cut childhood HCC incidence by ~70%; direct-acting antivirals cure HCV in >95% and reduce HCC risk by roughly 70%, though risk persists in established cirrhosis. MASLD is now the fastest-growing cause in Western countries.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Hepatitis_B
- Wikipedia: https://en.wikipedia.org/wiki/Hepatitis_B

## Connected records

- cancers: [Advanced hepatocellular carcinoma (BCLC C)](https://onco.cc/cancers/hcc-advanced/), [Early hepatocellular carcinoma (BCLC 0 and A)](https://onco.cc/cancers/hcc-early/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)
- technologies: [HCC surveillance in cirrhosis (ultrasound + AFP)](https://onco.cc/technologies/hcc-surveillance/), [HPV & HBV vaccination](https://onco.cc/technologies/hpv-vaccine/)
- pairings: [Caution: bevacizumab-based regimens with untreated varices](https://onco.cc/pairings/io-varices-caution/)
- people: [Jia Fan](https://onco.cc/people/fan-jia/)
- bottlenecks: [Most of the world has almost no cancer care](https://onco.cc/bottlenecks/b-global-access/), [Prevention we already have is not deployed](https://onco.cc/bottlenecks/b-prevention-adoption/)
- pathways: [Oncogenic viruses](https://onco.cc/pathways/oncogenic-viruses/)
- trials: [ORIENT-32](https://onco.cc/trials/orient-32/)

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