# HDAC10

Source: https://onco.cc/targets/hdac10/  
OnCo record `hdac10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HDAC10 (Polyamine deacetylase HDAC10) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.

## Summary

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, clinical 0.95). In OnCo, 1 product record names it (Tucidinostat (chidamide)).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: histone deacetylase 10; Polyamine deacetylase HDAC10; DKFZP761B039
- Tags: cancer-genes-wave
- Symbol: HDAC10
- Class: enzyme
- Biology: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.33 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908); Multiple myeloma: Open Targets association 0.55 with plasma cell myeloma (MONDO_0009693)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.95; UniProt keyword "DNA repair". Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18128: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18128
- UniProt Q969S8: https://www.uniprot.org/uniprotkb/Q969S8/entry
- NCBI Gene 83933: https://www.ncbi.nlm.nih.gov/gene/83933
- Ensembl ENSG00000100429: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100429

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)
- drugs: [Tucidinostat (chidamide)](https://onco.cc/drugs/tucidinostat/)

---
JSON: https://onco.cc/api/v1/entities/hdac10.json