# HERPUD1

Source: https://onco.cc/targets/herpud1/  
OnCo record `herpud1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.56, somatic mutation 0.68).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homocysteine inducible ER protein with ubiquitin like domain 1; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; KIAA0025; Mif1; HERPUD1-IT1
- Tags: cancer-genes-wave
- Symbol: HERPUD1
- Class: other
- Biology: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. Location: Endoplasmic reticulum membrane (UniProt). Locus 16q13 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13744: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13744
- UniProt Q15011: https://www.uniprot.org/uniprotkb/Q15011/entry
- NCBI Gene 9709: https://www.ncbi.nlm.nih.gov/gene/9709
- Ensembl ENSG00000051108: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000051108

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/herpud1.json