# HHIP

Source: https://onco.cc/targets/hhip/  
OnCo record `hhip` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, animal model 0.40, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: hedgehog interacting protein; Hedgehog-interacting protein; FLJ20992
- Tags: cancer-genes-wave
- Symbol: HHIP
- Class: other
- Biology: Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Location: Cell membrane; Secreted; Cytoplasm (UniProt). Locus 4q31.21 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14866: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14866
- UniProt Q96QV1: https://www.uniprot.org/uniprotkb/Q96QV1/entry
- NCBI Gene 64399: https://www.ncbi.nlm.nih.gov/gene/64399
- Ensembl ENSG00000164161: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164161

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/hhip.json