# HMGA2

Source: https://onco.cc/targets/hmga2/  
OnCo record `hmga2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HMGA2 (High mobility group protein HMGI-C) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.

## Summary

Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.

Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 1.00, animal model 0.36, genetic association 0.49, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: high mobility group AT-hook 2; High mobility group protein HMGI-C; HMGIC
- Tags: cancer-genes-wave
- Symbol: HMGA2
- Class: transcription
- Biology: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner. Location: Nucleus (UniProt). Locus 12q14.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254); Oral cavity cancer: Open Targets association 0.52 with oral cavity cancer (MONDO_0005515)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5009: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5009
- UniProt P52926: https://www.uniprot.org/uniprotkb/P52926/entry
- NCBI Gene 8091: https://www.ncbi.nlm.nih.gov/gene/8091
- Ensembl ENSG00000149948: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149948

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/)

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JSON: https://onco.cc/api/v1/entities/hmga2.json