# HNF1B

Source: https://onco.cc/targets/hnf1b/  
OnCo record `hnf1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.

## Summary

Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1.

Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.92, affected pathway 0.35, literature 0.98, genetic association 0.88, animal model 0.25).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: HNF1 homeobox B; Hepatocyte nuclear factor 1-beta; LFB3; VHNF1; HNF1beta; MODY5; HNF1β; TCF2
- Tags: cancer-genes-wave
- Symbol: HNF1B
- Class: transcription
- Biology: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1. Location: Nucleus (UniProt). Locus 17q12 (HGNC).
- Where found: Renal cell carcinoma: Open Targets association 0.71 with renal cell carcinoma (MONDO_0005086); Ovarian cancer: Open Targets association 0.54 with ovarian cancer (MONDO_0008170)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11630: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11630
- UniProt P35680: https://www.uniprot.org/uniprotkb/P35680/entry
- NCBI Gene 6928: https://www.ncbi.nlm.nih.gov/gene/6928
- Ensembl ENSG00000275410: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000275410

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/hnf1b.json