# HNF4G

Source: https://onco.cc/targets/hnf4g/  
OnCo record `hnf4g` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.63).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: hepatocyte nuclear factor 4 gamma; Hepatocyte nuclear factor 4-gamma; NR2A2
- Tags: cancer-genes-wave
- Symbol: HNF4G
- Class: transcription
- Biology: Transcription factor. Has a lower transcription activation potential than HNF4-alpha. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5026: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5026
- UniProt Q14541: https://www.uniprot.org/uniprotkb/Q14541/entry
- NCBI Gene 3174: https://www.ncbi.nlm.nih.gov/gene/3174
- Ensembl ENSG00000164749: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164749

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/hnf4g.json