# HNRNPH1

Source: https://onco.cc/targets/hnrnph1/  
OnCo record `hnrnph1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.

## Summary

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heterogeneous nuclear ribonucleoprotein H1; Heterogeneous nuclear ribonucleoprotein H; hnRNPH; HNRPH1
- Tags: cancer-genes-wave
- Symbol: HNRNPH1
- Class: other
- Biology: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Location: Nucleus, nucleoplasm (UniProt). Locus 5q35.3 (HGNC).
- Where found: Mantle cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5041: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5041
- UniProt P31943: https://www.uniprot.org/uniprotkb/P31943/entry
- NCBI Gene 3187: https://www.ncbi.nlm.nih.gov/gene/3187
- Ensembl ENSG00000169045: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169045

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Mantle cell lymphoma](https://onco.cc/cancers/mantle-cell-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/hnrnph1.json