# HNRNPU

Source: https://onco.cc/targets/hnrnpu/  
OnCo record `hnrnpu` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HNRNPU (Heterogeneous nuclear ribonucleoprotein U) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.

## Summary

DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organisation, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organisation through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localisation of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heterogeneous nuclear ribonucleoprotein U; Heterogeneous nuclear ribonucleoprotein U; SAF-A; FLJ37978; FLJ30202; HNRPU; HNRNPU-AS1; C1orf199; NCRNA00201
- Tags: cancer-genes-wave
- Symbol: HNRNPU
- Class: transcription
- Biology: DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organisation, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organisation through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localisation of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation. Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Location: Nucleus; Nucleus matrix; Chromosome; Nucleus speckle (UniProt). Locus 1q44 (HGNC).
- Where found: Burkitt lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5048: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5048
- UniProt Q00839: https://www.uniprot.org/uniprotkb/Q00839/entry
- NCBI Gene 3192: https://www.ncbi.nlm.nih.gov/gene/3192
- Ensembl ENSG00000153187: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153187

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Burkitt lymphoma](https://onco.cc/cancers/burkitt-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/hnrnpu.json