# HOOK3

Source: https://onco.cc/targets/hook3/  
OnCo record `hook3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOOK3 (Protein Hook homolog 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.00, somatic mutation 0.85).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: hook microtubule tethering protein 3; Protein Hook homolog 3; HK3
- Tags: cancer-genes-wave
- Symbol: HOOK3
- Class: other
- Biology: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Location: Cytoplasm, cytoskeleton; Golgi apparatus (UniProt). Locus 8p11.21 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23576: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23576
- UniProt Q86VS8: https://www.uniprot.org/uniprotkb/Q86VS8/entry
- NCBI Gene 84376: https://www.ncbi.nlm.nih.gov/gene/84376
- Ensembl ENSG00000168172: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168172

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/hook3.json