# HOXA13

Source: https://onco.cc/targets/hoxa13/  
OnCo record `hoxa13` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOXA13 (Homeobox protein Hox-A13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, animal model 0.58, genetic association 0.25, somatic mutation 0.93). In OnCo, 1 product record names it (Cxbladder).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homeobox A13; Homeobox protein Hox-A13; HOX1J; HOX1
- Tags: cancer-genes-wave
- Symbol: HOXA13
- Class: transcription
- Biology: Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 7p15.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5102: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5102
- UniProt P31271: https://www.uniprot.org/uniprotkb/P31271/entry
- NCBI Gene 3209: https://www.ncbi.nlm.nih.gov/gene/3209
- Ensembl ENSG00000106031: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106031

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- drugs: [Cxbladder](https://onco.cc/drugs/cxbladder/)

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JSON: https://onco.cc/api/v1/entities/hoxa13.json