# HOXB13

Source: https://onco.cc/targets/hoxb13/  
OnCo record `hoxb13` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.

## Summary

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.99, genetic association 0.86, somatic mutation 0.30, animal model 0.38). In OnCo, 1 product record names it (Breast Cancer Index).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homeobox B13; Homeobox protein Hox-B13
- Tags: cancer-genes-wave
- Symbol: HOXB13
- Class: transcription
- Biology: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Location: Nucleus (UniProt). Locus 17q21.32 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.74 with prostate cancer (MONDO_0008315); CIViC evidence names this disease; Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5112: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5112
- UniProt Q92826: https://www.uniprot.org/uniprotkb/Q92826/entry
- NCBI Gene 10481: https://www.ncbi.nlm.nih.gov/gene/10481
- Ensembl ENSG00000159184: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000159184

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Prostate cancer](https://onco.cc/cancers/prostate/)
- drugs: [Breast Cancer Index](https://onco.cc/drugs/breast-cancer-index/)

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JSON: https://onco.cc/api/v1/entities/hoxb13.json