# HOXC13

Source: https://onco.cc/targets/hoxc13/  
OnCo record `hoxc13` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.

## Summary

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, animal model 0.67, somatic mutation 0.77). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homeobox C13; Homeobox protein Hox-C13; HOX3; HOX3G
- Tags: cancer-genes-wave
- Symbol: HOXC13
- Class: tumor-suppressor
- Biology: Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes. Location: Nucleus (UniProt). Locus 12q13.13 (HGNC).
- Where found: Breast cancer: IntOGen driver in 1 cohort (BRCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5125: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5125
- UniProt P31276: https://www.uniprot.org/uniprotkb/P31276/entry
- NCBI Gene 3229: https://www.ncbi.nlm.nih.gov/gene/3229
- Ensembl ENSG00000123364: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123364

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/hoxc13.json