# HOXD11

Source: https://onco.cc/targets/hoxd11/  
OnCo record `hoxd11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOXD11 (Homeobox protein Hox-D11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.71, animal model 0.32, genetic association 0.37, somatic mutation 0.94).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homeobox D11; Homeobox protein Hox-D11; HOX4; HOX4F
- Tags: cancer-genes-wave
- Symbol: HOXD11
- Class: transcription
- Biology: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5134: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5134
- UniProt P31277: https://www.uniprot.org/uniprotkb/P31277/entry
- NCBI Gene 3237: https://www.ncbi.nlm.nih.gov/gene/3237
- Ensembl ENSG00000128713: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128713

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/hoxd11.json