# HOXD13

Source: https://onco.cc/targets/hoxd13/  
OnCo record `hoxd13` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOXD13 (Homeobox protein Hox-D13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, animal model 0.82, genetic association 0.00, somatic mutation 0.93).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homeobox D13; Homeobox protein Hox-D13; HOX4I
- Tags: cancer-genes-wave
- Symbol: HOXD13
- Class: transcription
- Biology: Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5136: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5136
- UniProt P35453: https://www.uniprot.org/uniprotkb/P35453/entry
- NCBI Gene 3239: https://www.ncbi.nlm.nih.gov/gene/3239
- Ensembl ENSG00000128714: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128714

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/hoxd13.json