# HOXD8

Source: https://onco.cc/targets/hoxd8/  
OnCo record `hoxd8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HOXD8 (Homeobox protein Hox-D8) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.

## Summary

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib and Dabrafenib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: homeobox D8; Homeobox protein Hox-D8; HOX4; HOX4E
- Tags: cancer-genes-wave
- Symbol: HOXD8
- Class: transcription
- Biology: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).
- Where found: Melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5139: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5139
- UniProt P13378: https://www.uniprot.org/uniprotkb/P13378/entry
- NCBI Gene 3234: https://www.ncbi.nlm.nih.gov/gene/3234
- Ensembl ENSG00000175879: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175879

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/hoxd8.json