# Human Protein Atlas

Source: https://onco.cc/collections/hpa/  
OnCo record `hpa` (Collection). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The Human Protein Atlas shows where in the body each protein is found, which tells you whether an ADC target is safe.

## Summary

The Human Protein Atlas maps protein expression across normal and cancer tissues by immunohistochemistry, complemented by single-cell and subcellular atlases, so a reader can see where in the body each protein is found and therefore whether an ADC target is likely to be safe. Its pathology atlas includes survival correlations, and the resource is essential for target expression screening. It is run by KTH and Uppsala and released under CC BY-SA. On OnCo it is linked to the technologies Antibody-drug conjugate (ADC) and Proteomics and phosphoproteomics, and it is cited by the bottleneck Preclinical results do not reproduce and by the idea Only use antibodies proven to hit their target with knockout controls.

## Fields

- Kind: Collection
- Last checked: 2026-09-04
- URL: https://www.proteinatlas.org
- Holds: Protein expression across normal and cancer tissues by IHC, plus single-cell and subcellular atlases.
- Licence: CC BY-SA 3.0

## Sources

- Human Protein Atlas: https://www.proteinatlas.org

## Connected records

- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/), [Proteomics & phosphoproteomics](https://onco.cc/technologies/proteomics/)
- bottlenecks: [Preclinical results do not reproduce](https://onco.cc/bottlenecks/b-reproducibility/)
- ideas: [Only use antibodies proven to hit their target with knockout controls](https://onco.cc/ideas/idea-tr2-antibody-validation-mandate/)

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JSON: https://onco.cc/api/v1/entities/hpa.json