# HRAS

Source: https://onco.cc/targets/hras/  
OnCo record `hras` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HRAS (GTPase HRas) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Thyroid cancer, Sarcomas and 5 more.

## Summary

Signal transducer in the Ras-MAPK signalling pathway that regulates cell proliferation and survival. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Recognised by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.

CIViC holds 24 clinical evidence items and 2 assertions across 12 variants, naming Vemurafenib, Selumetinib, Cetuximab and Erlotinib and others. Open Targets scores its association with cancer at 0.90 (direct and indirect evidence; datatypes genetic literature 0.79, clinical 0.16, affected pathway 0.90, literature 0.98, genetic association 0.86, somatic mutation 0.97, animal model 0.43). IntOGen calls it a driver in 23 cohorts (23 activating, 0 loss-of-function), covering Angiosarcoma, Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Colorectal Adenocarcinoma, Cutaneous Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma and others. In OnCo, 1 product record names it (JYP0015).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: HRas proto-oncogene, GTPase; GTPase HRas; HRAS1
- Tags: cancer-genes-wave
- Symbol: HRAS
- Class: oncogene
- Biology: Signal transducer in the Ras-MAPK signalling pathway that regulates cell proliferation and survival. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Recognised by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Location: Cell membrane; Golgi apparatus; Golgi apparatus membrane; Nucleus (UniProt). Locus 11p15.5 (HGNC).
- Where found: Bladder & urothelial cancer: Open Targets association 0.79 with urinary bladder cancer (MONDO_0001187); CIViC evidence names this disease; Thyroid cancer: Open Targets association 0.77 with thyroid cancer (MONDO_0002108); CIViC evidence names this disease; Sarcomas: Open Targets association 0.67 with sarcoma (MONDO_0005089); Head and neck squamous cell carcinoma: Open Targets association 0.66 with head and neck squamous cell carcinoma (MONDO_0010150); CIViC evidence names this disease; Neuroendocrine tumours: Open Targets association 0.64 with neuroendocrine neoplasm (MONDO_0019496); Prostate cancer: IntOGen driver in 4 cohorts (PRAD, PROSTATE)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.16; IntOGen calls it an activating (Act) driver in 23 cohorts; CIViC holds 24 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Skin Squamous Cell Carcinoma; Follicular Thyroid Carcinoma.

## Sources

- HGNC HGNC:5173: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5173
- UniProt P01112: https://www.uniprot.org/uniprotkb/P01112/entry
- NCBI Gene 3265: https://www.ncbi.nlm.nih.gov/gene/3265
- Ensembl ENSG00000174775: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000174775

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Thyroid cancer](https://onco.cc/cancers/thyroid/)
- drugs: [JYP0015](https://onco.cc/drugs/jyp0015/)
- pathways: [Bladder cancer (KEGG map)](https://onco.cc/pathways/bladder-cancer-signalling/)

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JSON: https://onco.cc/api/v1/entities/hras.json