# HSP90AB1

Source: https://onco.cc/targets/hsp90ab1/  
OnCo record `hsp90ab1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.

## Summary

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heat shock protein 90 alpha family class B member 1; Heat shock protein HSP 90-beta; HSPC2; HSPCB
- Tags: cancer-genes-wave
- Symbol: HSP90AB1
- Class: tumor-suppressor
- Biology: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. Location: Cytoplasm; Melanosome; Nucleus; Secreted (UniProt). Locus 6p21.1 (HGNC).
- Where found: Melanoma: IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5258: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5258
- UniProt P08238: https://www.uniprot.org/uniprotkb/P08238/entry
- NCBI Gene 3326: https://www.ncbi.nlm.nih.gov/gene/3326
- Ensembl ENSG00000096384: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000096384

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/hsp90ab1.json