# HSP90B1

Source: https://onco.cc/targets/hsp90b1/  
OnCo record `hsp90b1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Temozolomide and Onalespib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heat shock protein 90 beta family member 1; Endoplasmin; GP96; GRP94; TRA1
- Tags: cancer-genes-wave
- Symbol: HSP90B1
- Class: enzyme
- Biology: ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10. Location: Endoplasmic reticulum lumen; Sarcoplasmic reticulum lumen; Melanosome (UniProt). Locus 12q23.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glioma.

## Sources

- HGNC HGNC:12028: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12028
- UniProt P14625: https://www.uniprot.org/uniprotkb/P14625/entry
- NCBI Gene 7184: https://www.ncbi.nlm.nih.gov/gene/7184
- Ensembl ENSG00000166598: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166598

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/hsp90b1.json