# HSPA5

Source: https://onco.cc/targets/hspa5/  
OnCo record `hspa5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HSPA5 (Endoplasmic reticulum chaperone BiP) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR).

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Fluorouracil.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heat shock protein family A (Hsp70) member 5; Endoplasmic reticulum chaperone BiP; BiP; GRP78
- Tags: cancer-genes-wave
- Symbol: HSPA5
- Class: enzyme
- Biology: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerisation of ERN1/IRE1, thereby inactivating ERN1/IRE1. Also binds and inactivates EIF2AK3/PERK in unstressed cells. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerisation and subsequent activation. Location: Endoplasmic reticulum lumen; Melanosome; Cytoplasm; Cell surface (UniProt). Locus 9q33.3 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5238: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5238
- UniProt P11021: https://www.uniprot.org/uniprotkb/P11021/entry
- NCBI Gene 3309: https://www.ncbi.nlm.nih.gov/gene/3309
- Ensembl ENSG00000044574: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000044574

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/hspa5.json