# HSPG2

Source: https://onco.cc/targets/hspg2/  
OnCo record `hspg2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.

## Summary

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heparan sulfate proteoglycan 2; Basement membrane-specific heparan sulfate proteoglycan core protein; perlecan; PRCAN; SJS1
- Tags: cancer-genes-wave
- Symbol: HSPG2
- Class: oncogene
- Biology: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularisation. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Location: Secreted, extracellular space, extracellular matrix, basement membrane; Secreted (UniProt). Locus 1p36.12 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5273: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5273
- UniProt P98160: https://www.uniprot.org/uniprotkb/P98160/entry
- NCBI Gene 3339: https://www.ncbi.nlm.nih.gov/gene/3339
- Ensembl ENSG00000142798: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142798

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/)

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JSON: https://onco.cc/api/v1/entities/hspg2.json