# HSPH1

Source: https://onco.cc/targets/hsph1/  
OnCo record `hsph1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.

## Summary

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.

CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Fluorouracil, Oxaliplatin and Cisplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: heat shock protein family H (Hsp110) member 1; Heat shock protein 105 kDa; HSP105B; KIAA0201; HSP105A; NY-CO-25
- Tags: cancer-genes-wave
- Symbol: HSPH1
- Class: other
- Biology: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Location: Cytoplasm (UniProt). Locus 13q12.3 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease; Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16969: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16969
- UniProt Q92598: https://www.uniprot.org/uniprotkb/Q92598/entry
- NCBI Gene 10808: https://www.ncbi.nlm.nih.gov/gene/10808
- Ensembl ENSG00000120694: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120694

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/hsph1.json