# ICE COMPRESS (SWOG, cooling or compression of limbs to prevent neuropathy)

Source: https://onco.cc/trials/ice-compress-swog/  
OnCo record `ice-compress-swog` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A large US trial testing whether cooling, squeezing or both protect the nerves in the hands and feet during chemotherapy. It is the trial expected to settle a question small studies have left open.

## Summary

ICE COMPRESS is a SWOG phase 3 trial with an estimated 777 participants comparing cryocompression therapy with pneumatic compression therapy of the limbs to prevent chemotherapy-induced peripheral neuropathy, with quality-of-life and biospecimen measures. ClinicalTrials.gov gives an estimated primary completion in August 2030.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-11-04
- Also known as: ICE COMPRESS; Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy
- Tags: machines-wave3
- Registry id: NCT05642611
- Phase: 3
- Setting: People with solid tumours starting neuropathy-causing chemotherapy, randomised between cryocompression and pneumatic compression approaches to the hands and feet
- Sponsor: SWOG Cancer Research Network
- Enrolled: 777

## Sources

- ClinicalTrials.gov NCT05642611: https://clinicaltrials.gov/study/NCT05642611

## Connected records

- technologies: [Frozen gloves, socks and compression for taxane nail and nerve damage](https://onco.cc/technologies/frozen-gloves-compression-taxane/), [Limb cryocompression devices for chemotherapy nerve damage (Paxman Neuropathy System, Hilotherm ChemoCare)](https://onco.cc/technologies/limb-cryocompression-devices/)
- companies: [SWOG Cancer Research Network](https://onco.cc/companies/swog/)
- roadmaps: [Comfort devices at the chemotherapy chair: scalp cooling, cold caps, limb cryocompression and infusion chairs](https://onco.cc/roadmaps/chemo-chair-comfort-devices-roadmap/)
- ideas: [Choose cold or compression for neuropathy by what patients can keep on](https://onco.cc/ideas/idea-mach-cold-or-compression-by-adherence/)

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